Strategies to Prevent Type 2 Diabetes


Comme c'est très long voilà l'extrait où l'on mentionne le NO :

" Potential mechanisms of action of the antihypertensive agents

The mechanisms of action whereby these medications prevent type 2 diabetes are speculative25. ACE inhibitors not only block the conversion of angiotensin I to angiotensin II, but also increase bradykinin levels through inhibition of kininase II-mediated degradation57,58. These higher levels lead to increased production of prostaglandins E^sub 1^ and E^sub 2^ and nitric oxide, which improve exercise-induced glucose metabolism59 and muscle sensitivity to insulin60-62, resulting in enhanced insulinmediated glucose uptake. Furthermore, the peripheral vasodilatory actions of ACE inhibitors and ARBs lead to an improvement in skeletal muscle blood flow, the primary target for insulin action and an important determinant of glucose uptake. This effectively increases the surface area for glucose exchange between the vascular bed and skeletal muscles. Clinical evidence supporting this effect has been provided by Morel and coworkers63, who have shown improved insulin sensitivity when enalapril was given for 12 weeks to 14 obese, hypertensive, and dyslipidemic patients. "

et les travaux reliant le NO au transport du glucose :
- Balon TW, Nadler JL. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 1997;82:359-63
- Fryer LG, Hajduch E, Rencurel F, et al. Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes 2000;49:1978-85
- Henriksen EJ, Jacob S, Kinnick TR, Youngblood EB, Schmit MB, Dietze GJ. ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxide. Am J Physiol 1999;277:R332-6

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